Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae

• DOI: 10.1038/s41467-022-33313-w
• Publication Date: 2022-09-24T11:04:03Z
• Authors: Ana Djukovic; María José Garzón; Cécile Canlet; Vitor Cabral; Rym Lalaoui; Marc García-Garcerá; Julia Rechenberger; Marie Tremblay-Fr...; Iván Peñaranda; Leonor Puchades-C...; Antonio Pineda-Lu...; Eva María Gonzále...; Miguel Salavert; José Luis López-H...; Miguel Á. Sanz; Jaime Sanz; Bernhard Kuster; Jean-Marc Rolain; Laurent Debrauwer; Karina B. Xavier; Joao B. Xavier; Carles Ubeda
• Keywords: Lactobacillus rhamnosus; Colonisation resistance; Commensalism

Infections by multidrug-resistant Enterobacteriaceae (MRE) are life-threatening to patients. The intestinal microbiome protects against MRE colonization, but antibiotics cause collateral damage commensals and open the way colonization subsequent infection. Despite significance of this problem, specific mechanisms that restrict remain largely unknown. Here, performing a multi-omic prospective study hospitalized patients combined with mice experiments, we find Lactobacillus is key, though not sufficient, gut colonization. rhamnosus murinus increase levels Clostridiales bacteria, which induces hostile environment for growth through increased butyrate reduced nutrient sources. This mechanism resistance, an interaction between spp. involving cooperation microbiota members, conserved in These results stress importance exploiting interactions developing effective probiotics prevent infections