A population-based matched cohort study of early pregnancy outcomes following COVID-19 vaccination and SARS-CoV-2 infection

• DOI: 10.1038/s41467-022-33937-y
• Publication Date: 2022-10-17T11:06:40Z
• Authors: Clara Calvert; Jade Carruthers; Cheryl Denny; Jack Donaghy; Sam Hillman; Lisa E. M. Hopcroft; Leanne Hopkins; Anna Goulding; Laura Lindsay; Terry McLaughlin; Emily Moore; Jiafeng Pan; Bob Taylor; Fatima Almaghrabi; Bonnie Auyeung; Krishnan Bhaskaran; Cheryl L. Gibbons; Srinivasa Vittal ...; Colin McCowan; Josie Murray; Maureen O’Leary; Lewis D. Ritchie; Syed Ahmar Shah; Colin R. Simpson; Chris Robertson; Aziz Sheikh; Sarah J. Stock; Rachael Wood
• Keywords: Pandemic

Abstract Data on the safety of COVID-19 vaccines in early pregnancy are limited. We conducted a national, population-based, matched cohort study assessing associations between vaccination and miscarriage prior to 20 weeks gestation and, separately, ectopic pregnancy. identified women Scotland vaccinated 6 preconception 19 days (for miscarriage; n = 18,780) or 2 ectopic; 10,570). Matched, unvaccinated from pre-pandemic pandemic periods were used as controls. Here we show no association (adjusted Odds Ratio [aOR], controls 1.02, 95% Confidence Interval [CI] 0.96–1.09) (aOR 1.13, CI 0.92–1.38). undertook additional analyses examining confirmed SARS-CoV-2 infection exposure similarly found with Our findings support current recommendations that remains safest way for pregnant protect themselves their babies COVID-19.