Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine

• DOI: 10.1038/s41467-022-35440-w
• Publication Date: 2022-12-16T14:03:59Z
• Authors: Guoyin Chen; Kai Hou; Nuo Yu; Peiling Wei; Tao Chen; Caihong Zhang; Shun Wang; Hongmei Liu; Ran Cao; Liping Zhu; Benjamin S. Hsiao; Meifang Zhu
• Keywords: Penetration (warfare); Waveguide

Abstract Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing the limited penetration of light difficult monitoring photo-media therapies, it is challenging apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) proposed, capable eliminating deeply seated tumor cells while lowering risks overtemperature (causes death healthy around tumor). The THFOW fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, shows remarkable soft tissue-affinity (low cytotoxicity, swelling stability, tissue-like Young’s modulus). Moreover, excellent propagation property with different wavenumbers (especially −0.32 dB cm −1 915 nm laser light), temperature-gated effect. relevant therapeutic strategy offer promising application for intelligent issue.