The gut microbiome-prostate cancer crosstalk is modulated by dietary polyunsaturated long-chain fatty acids

• DOI: 10.1038/s41467-024-45332-w
• Publication Date: 2024-04-23T18:03:04Z
• Authors: Gabriel Lachance; Karine Robitaille; Jalal Laaraj; Nikunj Gevariya; Thibault V. Varin; Andrei Feldiorean; Fanny Gaignier; Isabelle Bourdeau...; Hui Wen Xu; Tarek Hallal; Jean-François Pel...; Sidki Bouslama; Nadia Boufaied; Nicolas Derome; Alain Bergeron; Leigh Ellis; Ciriaco A. Piccir...; Frédéric Raymond; Yves Fradet; David P. Labbé; André Marette; Vincent Fradet
• Keywords: Crosstalk; Gut microbiome; Long chain

The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction fecal alpha-diversity correlating with increase tumour burden two distinct groups of hormonotherapy naïve patients and three murine models. Fecal transplantation (FMT) from high volume is sufficient stimulate the growth mouse revealing existence microbiome-cancer crosstalk. Analysis microbial-related pathways mice aggressive identifies enzymes responsible for metabolism long-chain fatty acids (LCFA). Supplementation LCFA omega-3 MAG-EPA reduce up-grading pre-prostatectomy Ruminococcaceae both butyrate levels patients. This suggests that beneficial effect rich diet mediated part by modulating crosstalk between microbes their metabolites men PCa.