Response of treatment-naive brain metastases to stereotactic radiosurgery

• DOI: 10.1038/s41467-024-47998-8
• Publication Date: 2024-05-02T19:01:56Z
• Authors: Chibawanye I. Ene; Christina Abi Faraj; Thomas H. Beckham; Jeffrey S. Weinberg; Clark R. Andersen; Ali S. Haider; Ganesh Rao; Sherise D. Ferguson; Christopher A. Al...; Betty Y. S. Kim; Amy B. Heimberger; Ian E. McCutcheon; Sujit S. Prabhu; Chenyang Michael ...; Amol J. Ghia; Susan L. McGovern; Caroline Chung; Mary Frances McAleer; Martin C. Tom; Subha Perni; Todd A. Swanson; Debra N. Yeboa; Tina M. Briere; Jason T. Huse; Gregory N. Fuller; Frederick F. Lang; Jing Li; Dima Suki; Raymond E. Sawaya
• Keywords: Male; Adult; Medical Sciences; Bioinformatics; Science; 610; Radiosurgery; Article; Biomedical Informatics; 0302 clinical medicine; 80 and over; Medical Specialties; Medicine and Health Sciences; Humans; Treatment Failure; Melanoma; Aged; Retrospective Studies; Aged, 80 and over; Brain Neoplasms; Q; Middle Aged; Magnetic Resonance Imaging; Tumor Burden; CNS cancer; Treatment Outcome; Oncology; Female

With improvements in survival for patients with metastatic cancer, long-term local control of brain metastases has become an increasingly important clinical priority. While consensus guidelines recommend surgery followed by stereotactic radiosurgery (SRS) lesions >3 cm, smaller (≤3 cm) treated SRS alone elicit variable responses. To determine factors influencing this response to SRS, we analyzed outcomes ≤3 cm diameter no prior systemic therapy frame-based single-fraction SRS. Following 259 out 1733 (15%) demonstrated MRI findings concerning treatment failure (LTF), which 202 /1733 (12%) LTF and 54/1733 (3%) had adverse radiation effect. Multivariate analysis tumor size (>1.5 melanoma histology were associated higher rates. Our results demonstrate that are not uniformly responsive suggest prospective studies evaluate the effect or combination on matched warranted. These will help establish multi-disciplinary improve while minimizing necrosis during metastasis cm.