Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis

• DOI: 10.1038/s41467-024-48629-y
• Publication Date: 2024-05-21T18:02:16Z
• Authors: Udit Singhal; Srinivas Nallandh...; Jeffrey J. Tosoian; Kevin Hu; Trinh M. Pham; Judith Stangl-Kre...; Chia-Jen Liu; Razeen Karim; Komal R. Plouffe; Todd M. Morgan; Marcin Cieslik; Roberta Lucianò; Shahrokh F. Shariat; Nadia Finocchio; Lucia Dambrosio; Claudio Doglioni; Arul M. Chinnaiyan; Scott A. Tomlins; Alberto Briganti; Ganesh S. Palapattu; Aaron M. Udager; Simpa S. Salami
• Keywords: Profiling (computer programming); Primary (astronomy); Distant metastasis

Abstract Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biological trajectory disease. Previous large-scale sequencing efforts have focused on evolutionary process in metastatic cancer, revealing a potential clonal progression castration resistance. However, origin synchronous lymph node (LN) metastases primary disease still unknown. Here, we perform multi-region, targeted next generation construct phylogenetic trees men LN metastasis better define pathologic features most likely spread LNs. Collectively, demonstrate combination histopathologic factors, including tumor grade, presence extra-prostatic extension, cellular morphology, oncogenic alterations are associated metastasis.