Chronic intracranial recordings in the globus pallidus reveal circadian rhythms in Parkinson’s disease

• DOI: 10.1038/s41467-024-48732-0
• Publication Date: 2024-05-30T11:05:00Z
• Authors: Jackson N. Cagle; Tiberio de Araujo; Kara A. Johnson; John Yu; Lauren Fanty; Filipe P. Sarmento; Simon Little; Michael S. Okun; Joshua K. Wong; Coralie de Hemptinne
• Keywords: Subthalamic Nucleus; Neurostimulation

Abstract Circadian rhythms have been shown in the subthalamic nucleus (STN) Parkinson’s disease (PD), but only a few studies focused on globus pallidus internus (GPi). This retrospective study investigates GPi circadian large cohort of subjects with PD (130 recordings from 93 subjects) activity chronically recorded their home environment. We found significant change between daytime and nighttime most (82.4%), reduction at 56.2% an increase 26.2%. higher frequency bands ( > 20 Hz) was more likely to decrease night patients taking extended-release levodopa medication. Our results suggest that fluctuations vary across individuals increased power might be due reemergence pathological neural activity. These findings should considered ensure successful implementation adaptive neurostimulation paradigms real-world.