Diastereoselective dearomatization of indoles via photocatalytic hydroboration on hydramine-functionalized carbon nitride

• DOI: 10.1038/s41467-024-48769-1
• Publication Date: 2024-05-22T19:01:34Z
• Authors: Qiao Zhang; Wengang Xu; Qiong Liu; Congjian Xia; Qi Shao; Lishuang Ma; Mingbo Wu
• Keywords: Hydroboration; Boranes; Carbon fibers; Carbon nitride

Abstract A protocol for trans -hydroboration of indole derivatives using heterogeneous photocatalysis with NHC-borane has been developed, addressing a persistent challenge in organic synthesis. The protocol, leveraging high crystalline vacancy-engineered polymeric carbon nitride as catalyst, enables diastereoselective synthesis, expanding substrate scope and complementing existing methods. approach emphasizes eco-friendliness, cost-effectiveness, scalability, making it suitable industrial applications, particularly renewable energy contexts. catalyst’s superior performance, attributed to its rich carbon-vacancies well-ordered structure, surpasses more expensive homogeneous alternatives, enhancing viability large-scale use. This innovation holds promise synthesizing bioactive compounds materials relevant medicinal chemistry beyond.