Synergistic collaboration between AMPs and non-direct antimicrobial cationic peptides

• DOI: 10.1038/s41467-024-51730-x
• Publication Date: 2024-08-25T10:02:07Z
• Authors: Zifan Ye; Lei Fu; Shuangyu Li; Ziying Chen; Jianhong Ouyang; Xinci Shang; Yanli Liu; Lianghui Gao; Yipeng Wang
• Keywords: Cathelicidin; Intracellular parasite

Non-direct antimicrobial cationic peptides (NDACPs) are components of the animal innate immune system. But their functions and association with (AMPs) incompletely understood. Here, we reveal a synergistic interaction between AMP AW1 NDACP AW2, which co-expressed in frog Amolops wuyiensis. AW2 enhances antibacterial activity both vitro vivo, while mitigating development bacterial resistance eradicating biofilms. synergistically damage membranes, facilitating cellular uptake intracellular target genomic DNA. Simultaneously, they trigger generation ROS bacteria, contributing to cell death upon reaching threshold level. Moreover, demonstrate that this effect AMPs NDACPs is prevalent across diverse species. These findings unveil robust previously unknown correlation as widespread defense strategy animals. Antimicrobial non-direct secreted response invasive pathogens. Ye et al show there these two types expressed from amphibian