mRNA delivery enabled by metal–organic nanoparticles

• DOI: 10.1038/s41467-024-53969-w
• Publication Date: 2024-11-08T03:08:24Z
• Authors: Yuang Gu; Jingqu Chen; Zhaoran Wang; Chang Liu; Tianzheng Wang; Chan-Jin Kim; Helena Durikova; Soraia Fernandes; Darryl N. Johnson; Robert De Rose; Christina Cortez-...; Frank Caruso
• Keywords: 570; 0303 health sciences; 03 medical and health sciences; Science; Q; 610; Article

mRNA therapeutics are set to revolutionize disease prevention and treatment, inspiring the development of platforms for safe effective delivery. However, current delivery face some challenges, including limited organ tropism nonvaccine applications inflammation induced by cationic nanoparticle components. Herein, we address these challenges through a versatile, noncationic platform whereby is assembled into poly(ethylene glycol)-polyphenol network stabilized metal ions. Screening range components relative compositional ratios affords library stable, noncationic, highly biocompatible metal-organic nanoparticles with robust transfection in vitro mice. Intravenous administration lead mRNA-containing enables predominant protein expression gene editing brain, liver, kidney, while tuned varying composition. This study opens an avenue realizing nanoparticle-enabled delivery, offering modular approach assembling health applications.