Maternal gut microbiota influences immune activation at the maternal-fetal interface affecting pregnancy outcome

• DOI: 10.1038/s41467-025-58533-8
• Publication Date: 2025-05-09T13:16:55Z
• Authors: Silvia Giugliano; Andrea Gatti; Martina Rusin; Tilo Schorn; Silvia Pimazzoni; Michela Calanni-P...; Valentina Fraccascia; Sara Carloni; Maria Rescigno

Preeclampsia is a leading cause of morbidity and mortality in pregnant women, affecting 5-8% gestations worldwide. Its development influenced by maternal immune abnormalities, metabolic disorders, gut dysbiosis. In this study, we show that dysbiosis C57BL/6J dams leads to increased fetal resorption, impaired placental altered vascularization. These adverse outcomes are associated with key pathological features preeclampsia, including hypoxia, endoplasmic reticulum (ER) stress reduction uterine natural killer (NK) cell numbers. Furthermore, significantly perturbs carbohydrate metabolism, which impairs NK IFN-γ secretion. Notably, glucose supplementation restores function reduces suggesting the observed impairment reversible dependent on lower glycolytic rate. findings highlight microbiota as player pivotal role modulating immunity pregnancy outcome. The results provide valuable insights into potential biomarkers suggest targeting may offer strategy for preventing preeclampsia.