Standardized multi-omics of Earth’s microbiomes reveals microbial and metabolite diversity
Omics
DOI:
10.1038/s41564-022-01266-x
Publication Date:
2022-11-28T17:13:05Z
AUTHORS (98)
ABSTRACT
Despite advances in sequencing, lack of standardization makes comparisons across studies challenging and hampers insights into the structure function microbial communities multiple habitats on a planetary scale. Here we present multi-omics analysis diverse set 880 community samples collected for Earth Microbiome Project. We include amplicon (16S, 18S, ITS) shotgun metagenomic sequence data, untargeted metabolomics data (liquid chromatography-tandem mass spectrometry gas chromatography spectrometry). used standardized protocols analytical methods to characterize communities, focusing relationships co-occurrences microbially related metabolites taxa environments, thus allowing us explore diversity at extraordinary In addition reference database metabolomic provide framework incorporating additional studies, enabling expansion existing knowledge form an evolving resource. demonstrate utility this by testing hypothesis that every microbe metabolite is everywhere but environment selects. Our results show exhibits turnover nestedness both environment, whereas relative abundances vary co-occur with specific consortia habitat-specific manner. additionally power certain chemistry, particular terpenoids, distinguishing Earth's environments (for example, terrestrial plant surfaces soils, freshwater marine animal stool), as well microbes including Conexibacter woesei (terrestrial soils), Haloquadratum walsbyi (marine deposits) Pantoea dispersa detritus). This Resource provides insight within from Earth, informing chemical ecology, foundation microbiome hosts environment.
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