A prenatal skin atlas reveals immune regulation of human skin morphogenesis

• DOI: 10.1038/s41586-024-08002-x
• Publication Date: 2024-10-16T16:03:44Z
• Authors: Nusayhah Hudaa Gopee; Elena Winheim; Bayanne Olabi; Chloe Admane; April Rose Foster; Ni Huang; Rachel A. Botting; Fereshteh Torabi; Dinithi Sumanaweera; Anh Phuong Le; Jin Kim; Luca Verger; Emily Stephenson; Diana Adão; Clarisse Ganier; Kelly Y. Gim; Sara A. Serdy; CiCi Deakin; Issac Goh; Lloyd Steele; Karl Annusver; Mohi-Uddin Miah; Win Min Tun; Pejvak Moghimi; Kwasi Amoako Kwakwa; Tong Li; Daniela Basurto L...; Ben Rumney; Catherine L. Tudor; Kenny Roberts; Nana-Jane Chipampe; Keval Sidhpura; Justin Englebert; Laura Jardine; Gary Reynolds; Antony Rose; Vicky Rowe; Sophie Pritchard; Ilaria Mulas; James Fletcher; Dorin-Mirel Popescu; Elizabeth Poyner; Anna Dubois; Alyson Guy; Andrew Filby; Steven Lisgo; Roger A. Barker; Ian A. Glass; Jong-Eun Park; Roser Vento-Tormo; Marina Tsvetomilo...; Peng He; John E. G. Lawrence; Josh Moore; Stephane Ballereau; Christine B. Hale; Vijaya Shanmugiah; David Horsfall; Neil Rajan; John A. McGrath; Edel A. O’Toole; Barbara Treutlein; Omer Bayraktar; Maria Kasper; Fränze Progatzky; Pavel Mazin; Jiyoon Lee; Laure Gambardella; Karl R. Koehler; Sarah A. Teichmann; Muzlifah Haniffa
• Keywords: Human skin

Human prenatal skin is populated by innate immune cells, including macrophages, but whether they act solely in immunity or have additional functions morphogenesis unclear. Here we assembled a comprehensive multi-omics reference atlas of human (7-17 post-conception weeks), combining single-cell and spatial transcriptomics data, to characterize the microanatomical tissue niches skin. This revealed that crosstalk between non-immune cells underpins formation hair follicles, implicated scarless wound healing crucial for angiogenesis. We systematically compared hair-bearing organoid (SkO) model derived from embryonic stem induced pluripotent adult