Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

• DOI: 10.1038/s41593-022-01029-1
• Publication Date: 2022-03-17T17:11:58Z
• Authors: Jose A. Mazzitelli; Leon C. D. Smyth; Kevin A. Cross; Taitea Dykstra; Jerry Sun; Siling Du; Tornike Mamuladze; Igor Smirnov; Justin Rustenhoven; Jonathan Kipnis
• Keywords: Meninges; Bone Marrow; Skull; Myeloid Cells; Head; Article; Cerebrospinal Fluid; 3. Good health

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.