Simultaneous human intracerebral stimulation and HD-EEG, ground-truth for source localization methods

• DOI: 10.1038/s41597-020-0467-x
• Publication Date: 2020-04-28T10:04:11Z
• Authors: Ezequiel Mikulan; Simone Russo; Sara Parmigiani; Simone Sarasso; Flavia Maria Zauli; Annalisa Rubino; Pietro Avanzini; Anna Cattani; Alberto Sorrentino; Steve Gibbs; Francesco Cardinale; Ivana Sartori; Lino Nobili; Marcello Massimini; Andrea Pigorini
• Keywords: Ground truth; Clinical Practice; Ranging; Human brain

Abstract Precisely localizing the sources of brain activity as recorded by EEG is a fundamental procedure and major challenge for both research clinical practice. Even though many methods algorithms have been proposed, their relative advantages limitations are still not well established. Moreover, these involve tuning multiple parameters, which no principled way selection exists yet. These uncertainties emphasized due to lack ground-truth validation testing. Here we present Localize-MI dataset, constitutes first open dataset that comprises electrical originating from precisely known locations inside living humans. High-density was single-pulse biphasic currents were delivered at intensities ranging 0.1 5 mA through stereotactically implanted electrodes in diverse regions during pre-surgical evaluation patients with drug-resistant epilepsy. The uses this range estimation vivo tissue conductivity development, testing forward inverse solution methods.