Effects of sintering temperature on surface morphology/microstructure, in vitro degradability, mineralization and osteoblast response to magnesium phosphate as biomedical material

• DOI: 10.1038/s41598-017-00905-2
• Publication Date: 2017-04-05T15:03:16Z
• Authors: Zhiwei Wang; Yuhai Ma; Jie Wei; Xiao Chen; Liehu Cao; Weizong Weng; Quan Li; Han Guo; Jiacan Su
• Keywords: 0301 basic medicine; Hot Temperature; Osteoblasts; Science; Q; R; Magnesium Compounds; Biocompatible Materials; Cell Differentiation; Article; Phosphates; 03 medical and health sciences; Calcification, Physiologic; Cell Line, Tumor; Medicine; Humans; Cell Proliferation

Abstract Magnesium phosphate (MP) was fabricated using a chemical precipitation method, and the biological performances of MP sintered at different temperatures as biomedical material investigated. The results indicated that densification crystallinity increased sintering temperature increased. As increased, degradability in PBS decreased, mineralization ability SBF significantly In addition, 800 °C (MP8) possessed lowest highest ability. Moreover, positive response MG63 cells to MP8 promoted cell spreading, proliferation, differentiation expressions osteogenic differentiation-related genes. Faster degradation MP0 resulted higher pH environments ion concentrations, which led negative responses osteoblasts. However, appropriate suitable This study demonstrated substantially affected surface morphology/microstructure, mineralization, osteoblasts magnesium phosphate.