Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration

• DOI: 10.1038/s41598-017-06471-x
• Publication Date: 2017-07-14T10:39:52Z
• Authors: Minjuan Bian; Xiaoye Du; Peiwei Wang; Jingang Cui; Jing Xu; Jiangping Gu; Teng Zhang; Yu Chen
• Keywords: Degeneration (medical)

Photoreceptor degeneration is a central pathology of various retinal degenerative diseases which currently lack effective therapies. Antioxidant and anti-inflammatory activities are noted for Panax notoginsenoside saponins (PNS) related saponin compound(s). However, the photoreceptor protective potentials PNS or compound(s) remain unknown. The current study revealed that protected against loss in bright light-exposed BALB/c mice. Combination ginsenoside Rb1 Rd, two major compounds PNS, recapitulated protection attenuated oxidative stress inflammatory changes. Rd partially alleviated all-trans-Retinal-induced ARPE19 cells. suppressed lipopolysaccharides (LPS)-induced proinflammatory gene expression RAW264.7 also modulated microRNA, miR-155 its direct target, SHIP1, LPS-stimulated SHIP1 was altered preceding extensive damage, maintained at normal level by combination. This work shows first time involved degeneration. Most importantly, novel combination justify further evaluation treatment disorders.