Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence

• DOI: 10.1038/s41598-018-19767-3
• Publication Date: 2018-01-24T12:23:48Z
• Authors: David Romeo-Guitart; Joaquim Forés; Mireia Herrando-G...; Raquel Valls; Tatiana Leiva-Rod...; Elena Galea; Francisco Gonzále...; Xavier Navarro; Valerie Petegnief; Assumpció Bosch; Mireia Coma; José Manuel Mas; Caty Casas
• Keywords: 0301 basic medicine; Peripheral Nervous System Diseases; Recovery of Function; Article; Cell Line; Nerve Regeneration; Rats; 3. Good health; Machine Learning; Rats, Sprague-Dawley; Mice; 03 medical and health sciences; Neuroprotective Agents; Spinal Cord; Artificial Intelligence; Animals; Wounds and Injuries; Female; Radiculopathy; Spinal Nerve Roots; Algorithms

Here we used a systems biology approach and artificial intelligence to identify neuroprotective agent for the treatment of peripheral nerve root avulsion. Based on accumulated knowledge neurodegenerative processes that occur in motoneurons after avulsion, built up protein networks converted them into mathematical models. Unbiased proteomic data from our preclinical models were machine learning algorithms restrictions be imposed solutions. Solutions allowed us combinations repurposed drugs as potential agents validated The best one, NeuroHeal, neuroprotected motoneurons, exerted anti-inflammatory properties promoted functional locomotor recovery. NeuroHeal endorsed activation Sirtuin 1, which was essential its effect. These results support value network-centric approaches drug discovery demonstrate efficacy adjuvant with surgical repair nervous system trauma.