Lipid profile of cerebrospinal fluid in multiple sclerosis patients: a potential tool for diagnosis

• DOI: 10.1038/s41598-019-47906-x
• Publication Date: 2019-08-05T10:02:59Z
• Authors: L. Nogueras; H. Gonzalo; M. Jové; J. Sol; A. Gil-Sanchez; J. V. Hervás; P. Valcheva; C. Gonzalez-Mingot; M. J. Solana; S. Peralta; R. Pamplona; L. Brieva
• Keywords: Neuropathology; Lipidome; Arachidic acid; Etiology

Abstract Multiple sclerosis (MS) is a complex multifactorial neuropathology. Although its etiology remains unclear, it has been demonstrated that the immune system attacks myelin, leading to demyelination and axonal damage. The involvement of lipids as one main components myelin sheaths in MS other demyelinating diseases postulated. However, still matter debate whether specific alteration patterns exist over disease course. Here, using lipidomic approach, we that, at time diagnosis, cerebrospinal fluid patients presented differences 155 lipid species, 47 which were identified. An initial hierarchical clusterization was used classify based on presence 25 lipids. When supervised method applied order refine this classification, signature obtained. This composed 15 molecules belonging five different families including fatty acids (FAs). FA-targeted approach revealed two members family: 18:3n3 20:0 (arachidic acid). These results reveal CSF diagnosis might be considered potential diagnostic tool.