Comparative analysis of racial differences in breast tumor microbiome

• DOI: 10.1038/s41598-020-71102-x
• Publication Date: 2020-08-24T10:04:26Z
• Authors: Srikantha Thyagar...; Yan Zhang; Santosh Thapa; Michael S. Allen; Nicole Phillips; Pankaj Chaudhary; Meghana V. Kashyap; Jamboor K. Vishwa...
• Keywords: Adult; 0301 basic medicine; Receptor, ErbB-2; Microbiota; Triple Negative Breast Neoplasms; Biodiversity; Hispanic or Latino; Middle Aged; Article; White People; 3. Good health; Black or African American; 03 medical and health sciences; Receptors, Estrogen; RNA, Ribosomal, 16S; Ethnicity; Humans; Female; Receptors, Progesterone; Aged; Retrospective Studies

Abstract Studies have demonstrated that environmental, host genetic, and socioeconomic factors influence the breast cancer prevalence landscape with a far-reaching on racial disparity to subtypes of cancer. To understand whether tissue harbors race-specific microbiota, we performed 16S rRNA gene-based sequencing retrospective tumor matched normal adjacent (NAT) samples collected from Black non-Hispanic (BNH) White (WNH) women. Analysis Triple Negative Breast (TNBC) Positive Cancer (TPBC) tissues for microbiota composition revealed significant differences in relative abundance specific taxa at both phylum genus levels between WNH BNH women cohorts. Our main findings are microbial diversity as measured by Shannon index was significantly lower TNBC compared NAT zone. In contrast, cohort had an inverse pattern index, when NAT. Unweighted Principle Coordinates (PCoA) distinct clustering