Urinary concentrations of neonicotinoid insecticides were related to renal tubular dysfunction and neuropsychological complaints in Dry-zone of Sri Lanka

• DOI: 10.1038/s41598-021-01732-2
• Publication Date: 2021-11-18T11:06:20Z
• Authors: Kumiko Taira; Tomonori Kawakami; Sujithra Kaushali...; H. M. Ayala S. He...; Yoshinori Ikenaka; Kazutoshi Fujioka; Madhubhani Hemach...; Nirmalie Pallewatta; Yoshiko Aoyama; Mayumi Ishizuka; Jean-Marc Bonmatin; Makiko Komori
• Keywords: Thiacloprid; Neonicotinoid; Acetamiprid; Clothianidin

Abstract Neonicotinoids are systemic insecticides used since the 1990’s , that possess renal tubular toxicity. We conducted a field-based descriptive study in North Central Dry-zone of Sri Lanka, where chronic kidney disease (CKD) unknown etiology has been increasing 1990’s. To elucidate relationship between dysfunctions and urinary neonicotinoids concentrations, we collected spot urine samples from15 CKD patients, 15 family members, 62 neighbors 2015, analyzed two biomarkers, Cystatin-C L-FABP, quantified seven metabolite N -desmethyl-acetamiprid by LC–MS/MS; investigated their symptoms using questionnaire. L-FABP had positive correlation ( p < 0.001). -Desmethyl-acetamiprid was detected 92.4% samples, followed dinotefuran (17.4%), thiamethoxam clothianidin (9.8%), thiacloprid imidacloprid. Dinotefuran have never registered Lanka. In High group (> 70 μg/gCre, n = 7), higher concentration 0.009), Zero (< LOQ, 0.013), 0.049), 0.035), more complaints chest pains, stomachache, skin eruption diarrhea 0.05) were found than Normal (n 78). Urinary may be one potential risk factors for dysfunction this area.