In vitro assessment of intra-operative and post-operative environment in reducing bladder cancer recurrence

• DOI: 10.1038/s41598-021-04035-8
• Publication Date: 2022-01-07T11:03:34Z
• Authors: Ryan Tsz-Hei Tse; Hongda Zhao; Christine Yim-Pin...; Angel Wing-Yan Kong; Ronald Cheong-Kin...; Ka-Fai To; Chi-Fai Ng; Jeremy Yuen-Chun ...
• Keywords: Mitomycin C; Cancer cell lines

Urinary bladder cancer is a common worldwide. Currently, the modality of treating and monitoring wide. Nonetheless, high recurrence rate non-muscle-invasive after surgical resection still unsatisfactory. Hereby, our study demonstrated whether intra-operative post-operative environments will affect utilizing in vitro cell line model. Bladder lines were submerged four different irrigating fluids for assessing their tumorigenic properties. Our results showed that sterile water performed best terms magnitude cytotoxicity to lines. Besides, we also investigated cytotoxic effects agents as well mitomycin C (MMC) normothermic hyperthermic conditions. We observed MMC had an increased effect Altogether, could be translated into clinical practice future by manipulating conditions order lower chance residual cells reimplant onto bladder, which turns, reducing cancers.