Co-expression of cancer-testis antigens of MAGE-A6 and MAGE-A11 is associated with tumor aggressiveness in patients with bladder cancer

• DOI: 10.1038/s41598-021-04510-2
• Publication Date: 2022-01-12T11:02:59Z
• Authors: Monireh Mohsenzad...; Mahdieh Razmi; Somayeh Vafaei; Maryam Abolhasani; Zahra Madjd; Leili Saeednejad ...; Laleh Sharifi
• Keywords: Lamina propria

Melanoma antigen gene (MAGE)-A6 and MAGE-A11 are two of the most cancer-testis antigens overexpressed in various types cancers. However, clinical prognosis value MAGE-A6 co-expression pathophysiology bladder is unknown. Three studies were selected from GEO databases order to introduce common genes that involved cancer. Then immunohistochemical analysis for staining pattern clinicopathological significance suggested markers, MAGE-A11, performed 199 213 paraffin-embedded cancer with long adjacent normal tissues, respectively. A significant positive correlation was found between both nuclear cytoplasmic expressions as well expression histological grade, PT stage, lamina propria invasion, LP/ muscularis (L/M) involvement (all p-values terms H-score < 0.0001). Additionally, differences MAGE-A6/MAGE-A11 phenotypes tumor size (P = 0.007, P 0.043, respectively), different grades, LP involvement, L/M The current study added these novel markers settlement might be considered an admirable target immunotherapy.