Association of mannose-binding lectin 2 gene polymorphisms with Guillain-Barré syndrome

• DOI: 10.1038/s41598-022-09621-y
• Publication Date: 2022-04-06T15:03:47Z
• Authors: Israt Jahan; Shoma Hayat; Mir M. Khalid; Rijwan U. Ahammad; Asaduzzaman Asad; Badrul Islam; Quazi D. Mohammad; Bart C. Jacobs; Zhahirul Islam
• Keywords: Lectin pathway; Complement factor B; Pathogenesis

Abstract Complement activation plays a critical role in the pathogenesis of Guillain-Barré syndrome (GBS), debilitating immune-mediated neuropathy. Mannose-binding lectin (MBL) is complement factor pathway which as genetic host may influence susceptibility or severity GBS. We investigated frequency MBL2 promoter (− 550H/L and − 221X/Y) functional region (exon 1 A/O) polymorphisms their association with disease susceptibility, clinical features serum MBL among GBS patients ( n = 300) healthy controls Bangladesh. The median patient age was 30 years (IQR: 18–42; males, 68%). were not significantly associated compared to controls. HL heterozygosity mild disability at enrolment P 0.0145, OR, 95% CI 2.1, 1.17–3.82). HY, YA, HA HYA heterozygous haplotypes more common mildly affected 0.0067, 0.0086, 0.0075, 0.0032, respectively) than severely Reduced LL, OO no variants severity. No significant observed between electrophysiological variants, recent Campylobacter jejuni infection anti-ganglioside (GM1) antibody responses In conclusion, gene are related reduced