Clinical impact of and microbiological risk factors for qacA/B positivity in ICU-acquired ST5-methicillin-resistant SCCmec type II Staphylococcus aureus bacteremia

• DOI: 10.1038/s41598-022-15546-3
• Publication Date: 2022-07-06T10:03:29Z
• Authors: Haein Kim; Sunghee Park; Hyeonji Seo; Hyemin Chung; Eun Sil Kim; Heungsup Sung; Mi-Na Kim; Seongman Bae; Jiwon Jung; Min Jae Kim; Sung-Han Kim; Sang-Oh Lee; Sang-Ho Choi; Yang Soo Kim; Yong Pil Chong
• Keywords: Bacteremia; SCCmec; Multilocus sequence typing

Concern about resistance to chlorhexidine has increased due the wide use of latter. The impact qacA/B and smr tolerance genes on outcome methicillin-resistant Staphylococcus aureus (MRSA) infections is unclear. We evaluated prevalence clinical of, microbiological risk factors for, in MRSA bacteremia. bacteremia that occurred more than two days after intensive care unit admission between January 2009 December 2018 was identified from a prospective cohort S. tertiary-care hospital South Korea. A total 183 blood isolates identified, major genotype found ST5-MRSA-II (87.4%). prevalences were 67.2% 3.8%, respectively. qacA/B-positive predominantly (96.7% [119/123]), dominant clone. In homogenous background, positivity independently associated with septic shock (aOR, 4.85), gentamicin 74.43), non-t002 spa type 74.12). have decreased significantly association decline t2460, despite increasing since 2010 (P < 0.001 for trend). Continuous surveillance qac genes, molecular characterization their plasmids, are needed understand role epidemiology.