The spatial–temporal distribution and etiological characteristics of hand-foot-and-mouth disease before and after EV‑A71 vaccination in Kunming, China, 2017–2020

• DOI: 10.1038/s41598-022-21312-2
• Publication Date: 2022-10-11T14:02:54Z
• Authors: Meifen Wang; Tao Chen; Junchao Peng; Yunjiao Luo; Lijiang Du; Zhiying Lu; Jianzhu He; Chunli Liu; Quan Gan; Wei Ma; Zhikuan Cun; Qiongmei Zheng; Weiying Chen; Yonglin Chen; Mei Han; Guojun Liu; Jiwei Li
• Keywords: Hand-foot-and-mouth disease; Etiology; Foot (prosody)

After vaccination with enterovirus 71 (EV-A71), the prevalence of hand-foot-and-mouth disease (HFMD) remained high, and spatial-temporal distribution enteroviruses changed. Therefore, it is essential to define temporal features, spatial distributions, epidemiological etiological characteristics HFMD in Kunming. Between 2017 2020, a total 36,540 children were diagnosed Kunming, including 32,754 enterovirus-positive clinical samples. Demographic, geographical, data cases acquired analyzed. Other replaced EV-A71, incidence EV-A71 decreased dramatically, whereas coxsackievirus A6 (CV-A6) A16 (CV-A16) had substantial outbreaks 2018 2019, respectively. The major minor peaks all extended for 2-4 months compared before vaccine. From 2019 CV-A6, as predominant serotype, showed only single peak. Although high was observed Guandu, Chenggong Xishan, annual different serotypes regions. In 2017, other most prevalent Shilin. 2018, CV-A16 CV-A6 Luquan Shilin, Jinning. A10 (CV-A10) Meanwhile, epidemic cycle 1 year, CV-A10 potential risk pathogens. varies at scales, associated pathogens has obvious regional differences seasonal trends. research on multivalent combined vaccines urgently needed, proper preventive protective measures could effectively control HFMD-like diseases.