Impact of topical cetylated fatty acid cream on hand osteoarthritis: a randomized, double-blind clinical trial

• DOI: 10.1038/s41598-025-88202-1
• Publication Date: 2025-02-07T06:26:05Z
• Authors: Sitthiphong Suwan...; Nitiphoom Sinnath...; Pormes Suwanno; Warangkana Fongsri; Boonsin Tangtraku...
• Keywords: CFA; Cetylated fatty acid; Science; Hand osteoarthritis; Q; R; Medicine; Hand OA; Article

In addition to topical non-steroidal anti-inflammatory drugs that are used in hand osteoarthritis, there other can reduce pain such as cetylated fatty acids. Previous studies have reported CFAs effective all knee OA patients, with slightly higher evidence for those advanced disease. The mechanism of and is similar. Furthermore, no previous on hand. Patients fulfilling the American College Rheumatology criteria participated this randomized, double-blind, placebo-controlled study. Eligible patients were over 40 years age, had at least one tender joint, a joint visual analog score 30-60 mm. received CFA (n = 36) or placebo twice daily six weeks. primary outcome was Functional Index Hand Osteoarthritis (FIHOA) 2, 4, 6 secondary measures included Visual Analog Score (VAS), Patient Global Assessment (PGA), skin irritation At baseline, statistically significant differences observed among assessment parameters. Upon concluding 6-week study period, it evident group exhibited notably lower mean compared (2.2 ± 1.9 vs. 3.2 2.2, P < 0.05) achieved superior PGA scores (2.1 1.7 3.1 0.05). However, disparity detected terms FIHOA between two groups. Additionally, adverse reactions by group, whereas reports documented group. Topical demonstrate efficacy alleviating enhancing patient global satisfaction treatment osteoarthritis. more extended follow-up period imperative ascertain whether disparities exist safety profile functional outcomes placebo.