Kir4.1 channels in NG2-glia play a role in development, potassium signaling, and ischemia-related myelin loss

• DOI: 10.1038/s42003-018-0083-x
• Publication Date: 2018-06-22T11:32:02Z
• Authors: Feier Song; Xiaoqi Hong; Jiayu Cao; Guofen Ma; Yanfei Han; Carlos Cepeda; Zizhen Kang; Tianle Xu; Shumin Duan; Jieqing Wan; Xiaoping Tong
• Keywords: Neuroglia

The contribution of the inwardly rectifying K+ channel subtype Kir4.1 has been focused mainly on astrocytes, where they play important roles in maintenance resting membrane potential, extracellular uptake, and facilitation glutamate uptake central nervous system. Here, we report role channels NG2-glia during brain development, potassium signaling, an ischemic stroke disease model. are widely expressed development. In adult mouse hippocampus, constitute more than 80% inward currents. This large portion currents exhibits a deficit as initial response transient Further evidence indicates that deficits potentially cause axonal myelin loss ischemia through association with oligodendrocyte-specific protein (OSP/Claudin-11), which unravels potential therapeutic target treatment stroke.