Adipocyte browning and resistance to obesity in mice is induced by expression of ATF3

• DOI: 10.1038/s42003-019-0624-y
• Publication Date: 2019-10-25T12:20:45Z
• Authors: Ching-Feng Cheng; Hui-Chen Ku; Jing-Jy Cheng; Shi-Wei Chao; Hsiao-Fen Li; Pei-Fang Lai; Che-Chang Chang; Ming-Jaw Don; Hsi-Hsien Chen; Heng Lin
• Keywords: Lipogenesis; Hyperlipidemia; Orlistat

Abstract Billions of people have obesity-related metabolic syndromes such as diabetes and hyperlipidemia. Promoting the browning white adipose tissue has been suggested a potential strategy, but drug still needs to be identified. Here, genetic deletion activating transcription factor 3 ( ATF3 −/− ) in mice under high-fat diet (HFD) resulted obesity insulin resistance, which was abrogated by virus-mediated restoration. ST32da, synthetic inducer isolated from Salvia miltiorrhiza , promoted expression downregulate adipokine genes induce adipocyte suppressing carbohydrate-responsive element-binding protein–stearoyl-CoA desaturase-1 axis. Furthermore, ST32da increased reduced lipogenesis HFD-induced obese mice. The anti-obesity efficacy oral administration similar that clinical orlistat. Our study identified promising therapeutic for treating diet-induced related disorders.