T cell fate following Salmonella infection is determined by a STING-IRF1 signaling axis in mice

• DOI: 10.1038/s42003-019-0701-2
• Publication Date: 2019-12-11T12:44:58Z
• Authors: Sung-Moo Park; Tatsushi Omatsu; Yun Zhao; Naohiro Yoshida; Pankaj Shah; Rachid Zagani; Hans-Christian Re...
• Keywords: IRF1; Sting; Intracellular parasite

Abstract The innate immune response following infection with entero-invasive bacterial species is triggered upon release of cyclic di-guanylate monophosphate (c-di-GMP) into the host cell cytosol. Bacterial c-di-GMP activates intracellular Sensor Stimulator Interferon Genes (STING), encoded by Tmem173 in mice. Here we identify Regulatory Factor (IRF) 1 as a critical effector STING-mediated microbial DNA sensing that responsible for T H 17 generation mucosal system. We find STING activation induces IRF1-dependent transcriptional programs dendritic cells (DCs) define fate determination, including induction Gasdermin D, IL-1 family member cytokines, and enzymes eicosanoid synthesis. Our results show DCs are prerequisite antigen-specific subspecification to Salmonella typhimurium infection. identification STING-IRF1 signaling axis adaptive defense control will aid further understanding infectious disease mechanisms.