Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis

• DOI: 10.1038/s42003-020-01318-0
• Publication Date: 2020-10-23T10:06:00Z
• Authors: Qiyao Chai; Zhe Lu; Zhidong Liu; Yanzhao Zhong; Fuzhen Zhang; Changgen Qiu; Bingxi Li; Jing Wang; Lingqiang Zhang; Yu Pang; Cui Hua Liu
• Keywords: 0301 basic medicine; Lung Neoplasms; Sarcoidosis; Adenocarcinoma; Article; 3. Good health; Diagnosis, Differential; 03 medical and health sciences; Humans; Transcriptome; Lung; Tuberculosis, Pulmonary; Biomarkers; Signal Transduction

Abstract Previous reports have suggested a link between pulmonary tuberculosis (TB), which is caused by Mycobacterium (Mtb), and the development of lung adenocarcinoma (LUAD) sarcoidosis. Furthermore, these diseases share certain clinical similarities that can challenge differential diagnosis in some cases. Here, through comparison transcriptome-derived molecular signatures TB, LUAD sarcoidosis patients, we identify shared disease-related expression patterns. We also demonstrate MKI67 , an over-expressed gene TB LUAD, key mediator Mtb-promoted tumor cell proliferation, migration, invasion. Moreover, reveal distinct ossification-related signature, may be associated with activation BMP/SMAD/RUNX2 pathway Mtb-infected macrophages restrain mycobacterial survival promote osteogenic differentiation mesenchymal stem cells. Taken together, findings provide novel pathogenic links potential markers for better understanding