Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome

• DOI: 10.1038/s42003-020-01619-4
• Publication Date: 2021-02-20T16:02:53Z
• Authors: Gihyeon Kim; Misun Kim; Minji Kim; Changho Park; Youngmin Yoon; Doo-Hyeon Lim; Hyeonju Yeo; Seunghyun Kang; Yeong-Geun Lee; Nam-In Beak; Jongsung Lee; Sujeong Kim; Jee Young Kwon; Won Woo Choi; Charles Lee; Kyoung Wan Yoon; Hansoo Park; Dong-Geol Lee
• Keywords: Barrier function; Human skin; Streptococcus Pyogenes; Desquamation

Abstract An unbalanced microbial ecosystem on the human skin is closely related to diseases and has been associated with inflammation immune responses. However, little known about role of microbiome aging. Here, we report that Streptococcus species improved structure barrier function, thereby contributing anti-aging. Metagenomic analyses showed abundance in younger individuals or those having more elastic skin. Particularly, isolated pneumoniae , infantis thermophilus from face young individuals. Treatment secretions S. induced expression genes formation function cells. The application culture supernatant including Streptococcal marked improvements phenotypes such as elasticity, hydration, desquamation. Gene Ontology analysis revealed overlaps spermidine biosynthetic glycogen processes. -secreted contributed recovery through upregulation collagen lipid synthesis aged Overall, our data suggest into anti-aging clinical applications.