Functional role of the Frizzled linker domain in the Wnt signaling pathway

• DOI: 10.1038/s42003-022-03370-4
• Publication Date: 2022-05-05T10:08:32Z
• Authors: Seung-Bum Ko; Emiko Mihara; Yedarm Park; Kyeonghwan Roh; Chanhee Kang; Junichi Takagi; Injin Bang; Hee-Jung Choi
• Keywords: Linker; LRP6; WNT3A; LRP5

The Wnt signaling pathway plays a critical role in the developmental and physiological processes of metazoans. We previously reported that Frizzled4 (FZD4) linker domain an important Norrin binding signaling. However, question remains whether FZD contributes to general. Here, we show is involved affects downstream A FZD4 chimera, which was swapped with non-canonical receptor FZD6, impairs WNT3A suppresses recruitment LRP6 Disheveled, resulting reduced canonical similar effect observed for FZD6 chimera containing FZD1 showed WNT5A impaired ERK, JNK, AKT mediated pathways. Altogether, our results suggest specific intracellular