Keratin-mediated hair growth and its underlying biological mechanism

• DOI: 10.1038/s42003-022-04232-9
• Publication Date: 2022-11-19T06:02:28Z
• Authors: Seong Yeong An; Hyo-Sung Kim; So Yeon Kim; Se Young Van; Han Jun Kim; Jae-Hyung Lee; Song Wook Han; Il Keun Kwon; Chul-Kyu Lee; Sun Hee Do; Yu-Shik Hwang
• Keywords: Keratin 5; Keratin 8; Keratin 14; Root hair

Here we show that intradermal injection of keratin promotes hair growth in mice, which results from extracellular interaction with forming cells. Extracellular application induces condensation dermal papilla cells and the generation a P-cadherin-expressing cell population (hair germ) outer root sheath via keratin-mediated microenvironmental changes. Exogenous is reflected by finding exposure transforming factor beta 2 (TGFβ2)-induced apoptotic appears to be critical for germ formation. Immunodepletion or downregulation released expressed TGFβ2-induced negatively influences Our pilot study provides an evidence on initiating regeneration insight into biological function exposed epithelial tissue development.