Human whole genome genotype and transcriptome data for Alzheimer’s and other neurodegenerative diseases

• DOI: 10.1038/sdata.2016.89
• Publication Date: 2016-10-10T13:11:15Z
• Authors: Mariet Allen; Minerva M. Carras...; Cory Funk; Benjamin D. Heavner; Fanggeng Zou; Curtis S. Younkin; Jeremy D. Burgess; High-Seng Chai; Julia Crook; James A. Eddy; Hongdong Li; Ben Logsdon; Mette A. Peters; Kristen K. Dang; Xue Wang; Daniel Serie; Chen Wang; Thuy Nguyen; Sarah Lincoln; Kimberly Malphrus; Gina Bisceglio; Ma Li; Todd E. Golde; Lara M. Mangravite; Yan Asmann; Nathan D. Price; Ronald C. Petersen; Neill R. Graff-Ra...; Dennis W. Dickson; Steven G. Younkin; Nilüfer Ertekin-T...
• Keywords: Genome-wide Association Study

Abstract Previous genome-wide association studies (GWAS), conducted by our group and others, have identified loci that harbor risk variants for neurodegenerative diseases, including Alzheimer's disease (AD). Human are enriched polymorphisms affect gene expression, some known to associate with expression changes in the brain. Postulating many confer via transcriptional regulatory mechanisms, we analyzed levels brain tissue of subjects AD related diseases. Herein, describe collective datasets comprised GWAS data from 2,099 subjects; microarray 773 samples, 186 which also RNAseq; an independent cohort 556 samples RNAseq. We expect these datasets, available all qualified researchers, will enable investigators explore identify mechanisms contributing