Enhancing studies of the connectome in autism using the autism brain imaging data exchange II

• DOI: 10.1038/sdata.2017.10
• Publication Date: 2017-03-13T17:09:31Z
• Authors: Adriana Di Martino; David O’Connor; Bosi Chen; Kaat Alaerts; Jeffrey S. Anderson; Michal Assaf; Joshua H. Balsters; Leslie Baxter; Anita Beggiato; Sylvie Bernaerts; Laura M. E. Blanken; Susan Y. Bookheimer; B. Blair Braden; Lisa Byrge; F. Xavier Castell...; Mirella Dapretto; Richard Delorme; Damien A. Fair; Inna Fishman; Jacqueline Fitzge...; Louise Gallagher; R. Joanne Jao Keehn; Daniel P. Kennedy; Janet E. Lainhart; Beatriz Luna; Stewart H. Mostofsky; Ralph-Axel Müller; Mary Beth Nebel; Joel T. Nigg; Kirsten O’Hearn; Marjorie Solomon; Roberto Toro; Chandan J. Vaidya; Nicole Wenderoth; Tonya White; R. Cameron Craddock; Catherine Lord; Bennett Leventhal; Michael P. Milham
• Keywords: Statistics and Probability; Data Descriptor; Autism Spectrum Disorder; Autism; Intellectual and Developmental Disabilities (IDD); 1.1 Normal biological development and functioning; [SDV]Life Sciences [q-bio]; Funcional magnetic resonance imaging; Functional magnetic resonance imaging; Biological Psychology; 610; Autism spectrum disorders; Brain imaging; Funcional magnetic resonance imaging; Magnetic resonance imaging; Neuroscience; Neuroimaging; Brain imaging; Library and Information Sciences; Basic Behavioral and Social Science; Education; 03 medical and health sciences; Magnetic resonance imaging; 0302 clinical medicine; Behavioral and Social Science; Connectome; Psychology; 2.1 Biological and endogenous factors; Humans; Pediatric; Neurosciences; Autism spectrum disorders; Magnetic Resonance Imaging; Brain Disorders; Computer Science Applications; 3. Good health; Mental Health; Good Health and Well Being; Neurological; Biomedical Imaging; Mental health; Statistics, Probability and Uncertainty; Information Systems; Neuroscience

AbstractThe second iteration of the Autism Brain Imaging Data Exchange (ABIDE II) aims to enhance the scope of brain connectomics research in Autism Spectrum Disorder (ASD). Consistent with the initial ABIDE effort (ABIDE I), that released 1112 datasets in 2012, this new multisite open-data resource is an aggregate of resting state functional magnetic resonance imaging (MRI) and corresponding structural MRI and phenotypic datasets. ABIDE II includes datasets from an additional 487 individuals with ASD and 557 controls previously collected across 16 international institutions. The combination of ABIDE I and ABIDE II provides investigators with 2156 unique cross-sectional datasets allowing selection of samples for discovery and/or replication. This sample size can also facilitate the identification of neurobiological subgroups, as well as preliminary examinations of sex differences in ASD. Additionally, ABIDE II includes a range of psychiatric variables to inform our understanding of the neural correlates of co-occurring psychopathology; 284 diffusion imaging datasets are also included. It is anticipated that these enhancements will contribute to unraveling key sources of ASD heterogeneity.