A geographically-diverse collection of 418 human gut microbiome pathway genome databases

• DOI: 10.1038/sdata.2017.35
• Publication Date: 2017-04-11T13:15:12Z
• Authors: Aria S. Hahn; Tomer Altman; Kishori M. Konwar; Niels W. Hanson; Dongjae Kim; David A. Relman; David L. Dill; Steven J. Hallam
• Keywords: Human Microbiome Project; Compendium

Advances in high-throughput sequencing are reshaping how we perceive microbial communities inhabiting the human body, with implications for therapeutic interventions. Several large-scale datasets derived from hundreds of microbiome samples sourced multiple studies now publicly available. However, idiosyncratic data processing methods between introduce systematic differences that confound comparative analyses. To overcome these challenges, developed GutCyc, a compendium environmental pathway genome databases (ePGDBs) constructed 418 assembled using MetaPathways, enabling reproducible functional metagenomic annotation. We also generated metabolic network reconstructions each metagenome Pathway Tools software, empowering researchers and clinicians interested visualizing interpreting pathways encoded by gut microbiome. For first time, GutCyc provides consistent annotations predictions, making possible community analyses health disease states inflammatory bowel disease, Crohn's type 2 diabetes. products searchable online, or may be downloaded explored locally MetaPathways Tools.