Micro-computed tomography reconstructions of tibiae of stem cell transplanted osteogenesis imperfecta mice

• DOI: 10.1038/sdata.2018.100
• Publication Date: 2018-05-29T13:12:18Z
• Authors: Anna M. Ranzoni; Michelangelo Corc...; Timothy R. Arnett; Pascale V. Guillot
• Keywords: Statistics and Probability; 0301 basic medicine; Data Descriptor; Tibia; Stem Cells; X-Ray Microtomography; Library and Information Sciences; Osteogenesis Imperfecta; Computer Science Applications; Education; Mice; 03 medical and health sciences; Animals; Humans; Statistics, Probability and Uncertainty; Information Systems; Stem Cell Transplantation

AbstractMicro-computed tomography (micro-CT) is commonly used to assess bone quality and to evaluate the outcome of experimental therapies in animal models of bone diseases. Generating large datasets is however challenging and data are rarely made publicly available through shared repositories. Here we describe a dataset of micro-CT reconstructed scans of the proximal part of 21 tibiae from wild-type mice, osteogenesis imperfecta mice (homozygous oim/oim) and oim/oim mice transplanted with human amniotic fluid stem cells. The dataset contains, for each sample, 991 8-bit Bitmap reconstructed images and a 3D reconstruction of the bone in the PLY format, available at the online repository Figshare. In line with the increasing effort to make scientific datasets open-access, our data can be downloaded and used by other researchers to compare their observations with ours and to directly test scientific questions on osteogenesis imperfecta bones without the need to generate complete datasets.