A tissue-based draft map of the murine MHC class I immunopeptidome

Statistics and Probability Data Descriptor 610 Medicine & health Library and Information Sciences 1710 Information Systems Mass Spectrometry Education Mice 03 medical and health sciences 1706 Computer Science Applications Animals 1804 Statistics, Probability and Uncertainty 2613 Statistics and Probability 0303 health sciences Histocompatibility Antigens Class I 10040 Clinic for Neurology Computer Science Applications 3. Good health Mice, Inbred C57BL Organ Specificity 3309 Library and Information Sciences Statistics, Probability and Uncertainty Peptides 3304 Education Information Systems
DOI: 10.1038/sdata.2018.157 Publication Date: 2018-08-07T13:10:20Z
ABSTRACT
Abstract The large array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred as the MHC immunopeptidome. Although immunopeptidome ubiquitous in mammals and represents a critical component immune system, very little known, any species, about its composition across most tissues organs vivo . We applied mass spectrometry (MS) technologies draft first tissue-based atlas murine health. Peptides were extracted from 19 normal C57BL/6 mice prepared for MS injections, resulting total number 28,448 high-confidence H2D b /K -associated identified annotated atlas. This provides initial qualitative data explore tissue-specificity serves guide identify potential tumor-associated antigens various cancer models. Our shared via PRIDE (PXD008733), SysteMHC Atlas (SYSMHC00018) SWATH Atlas. anticipate that this unique dataset will be expanded future find wide applications basic translational immunology.
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