A tissue-based draft map of the murine MHC class I immunopeptidome
Statistics and Probability
Data Descriptor
610 Medicine & health
Library and Information Sciences
1710 Information Systems
Mass Spectrometry
Education
Mice
03 medical and health sciences
1706 Computer Science Applications
Animals
1804 Statistics, Probability and Uncertainty
2613 Statistics and Probability
0303 health sciences
Histocompatibility Antigens Class I
10040 Clinic for Neurology
Computer Science Applications
3. Good health
Mice, Inbred C57BL
Organ Specificity
3309 Library and Information Sciences
Statistics, Probability and Uncertainty
Peptides
3304 Education
Information Systems
DOI:
10.1038/sdata.2018.157
Publication Date:
2018-08-07T13:10:20Z
AUTHORS (13)
ABSTRACT
Abstract The large array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred as the MHC immunopeptidome. Although immunopeptidome ubiquitous in mammals and represents a critical component immune system, very little known, any species, about its composition across most tissues organs vivo . We applied mass spectrometry (MS) technologies draft first tissue-based atlas murine health. Peptides were extracted from 19 normal C57BL/6 mice prepared for MS injections, resulting total number 28,448 high-confidence H2D b /K -associated identified annotated atlas. This provides initial qualitative data explore tissue-specificity serves guide identify potential tumor-associated antigens various cancer models. Our shared via PRIDE (PXD008733), SysteMHC Atlas (SYSMHC00018) SWATH Atlas. anticipate that this unique dataset will be expanded future find wide applications basic translational immunology.
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