A tissue-based draft map of the murine MHC class I immunopeptidome
Statistics and Probability
Data Descriptor
610 Medicine & health
Library and Information Sciences
1710 Information Systems
Mass Spectrometry
Education
Mice
03 medical and health sciences
1706 Computer Science Applications
Animals
1804 Statistics, Probability and Uncertainty
2613 Statistics and Probability
0303 health sciences
Histocompatibility Antigens Class I
10040 Clinic for Neurology
Computer Science Applications
3. Good health
Mice, Inbred C57BL
Organ Specificity
3309 Library and Information Sciences
Statistics, Probability and Uncertainty
Peptides
3304 Education
Information Systems
DOI:
10.1038/sdata.2018.157
Publication Date:
2018-08-07T13:10:20Z
AUTHORS (13)
ABSTRACT
AbstractThe large array of peptides presented to CD8+ T cells by major histocompatibility complex (MHC) class I molecules is referred to as the MHC class I immunopeptidome. Although the MHC class I immunopeptidome is ubiquitous in mammals and represents a critical component of the immune system, very little is known, in any species, about its composition across most tissues and organs in vivo. We applied mass spectrometry (MS) technologies to draft the first tissue-based atlas of the murine MHC class I immunopeptidome in health. Peptides were extracted from 19 normal tissues from C57BL/6 mice and prepared for MS injections, resulting in a total number of 28,448 high-confidence H2Db/Kb-associated peptides identified and annotated in the atlas. This atlas provides initial qualitative data to explore the tissue-specificity of the immunopeptidome and serves as a guide to identify potential tumor-associated antigens from various cancer models. Our data were shared via PRIDE (PXD008733), SysteMHC Atlas (SYSMHC00018) and SWATH Atlas. We anticipate that this unique dataset will be expanded in the future and will find wide applications in basic and translational immunology.
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