Cancer risk following organ transplantation: a nationwide cohort study in Sweden

• DOI: 10.1038/sj.bjc.6601219
• Publication Date: 2003-09-30T18:20:18Z
• Authors: J Adami; H Gäbel; B Lindelöf; K Ekström; B Rydh; B Glimelius; A Ekbom; H-O Adami; F Granath
• Keywords: Kidney cancer

A substantial excess risk of lymphomas and nonmelanoma skin cancer has been demonstrated following organ transplantation. Large sample size long follow-up time may, however, allow more accurate estimates detailed understanding long-term risk. The objective the study was to assess nationwide cohort comprising 5931 patients who underwent transplantation kidney, liver or other organs during 1970-1997 in Sweden conducted. Complete accomplished through linkage databases. We used comparisons with entire Swedish population calculate standardised incidence ratios (SIRs), Poisson regression for multivariate internal analyses relative risks (RRs) 95% confidence intervals (CI). Overall, we observed 692 incident first cancers vs 171 expected (SIR 4.0; CI 3.7-4.4). confirmed marked excesses 56.2; 49.8-63.2), lip 53.3; 38.0-72.5) non-Hodgkin's lymphoma (NHL) 6.0; 4.4-8.0). Compared kidney transplantation, those received were at substantially higher NHL (RR 8.4; 4.3-16). Besides, found, significantly, about 20-fold vulva vagina, 10-fold anal cancer, five-fold oral cavity as well two- four-fold oesophagus, stomach, large bowel, urinary bladder, lung thyroid gland. In conclusion, entails a persistent, increased overall complex pattern many sites challenges current oncogenic infections that might become activated by immunologic alterations.