Diffuse EGFR staining is associated with reduced overall survival in locally advanced oesophageal squamous cell cancer

• DOI: 10.1038/sj.bjc.6602625
• Publication Date: 2005-06-28T17:37:21Z
• Authors: L Gibault; J-P Metges; V Conan-Charlet; P Lozac'h; M Robaszkiewicz; C Bessaguet; N Lagarde; A Volant
• Keywords: CD117

Squamous cell carcinoma of the oesophagus (SCCO) is still a pathology bad prognosis. Specific therapies are now developed against epidermal growth factor receptor (EGFR), human 2, c-kit (CD117), vascular endothelial (VEGF) and p53 protein. This study was aimed at assessing their expression in large series SCCO, as well potential therapeutic interest this pathology. Immunohistochemical these factors assessed retrospectively 107 cases SCCO with primary surgery, relationships to recurrence, metastasis overall survival on long-term follow-up. Human 2 CD117 were expressed less than 3% cases. Epidermal overexpressed 68.2 66.4% cases, VEGF 38.3%. overexpression significantly related invasion (P=0.023). Its diffuse positivity multivariate analysis higher local recurrence (P=0.006) lower (P=0.003), subgroup patients poor outcome who had received postoperative adjuvant treatment. These results highlight great prognostic evaluating EGFR locally advanced SCCO.