Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation

Diarrhea Male Polyomavirus Infections Time Factors virus; trapianti Hemorrhage Antibiotic Prophylaxis Middle Aged 3. Good health Tumor Virus Infections 03 medical and health sciences Fatal Outcome 0302 clinical medicine Leukemia, Myeloid Acute Disease Cystitis Humans Transplantation, Homologous Polyomavirus Vidarabine Bone Marrow Transplantation Hematuria
DOI: 10.1038/sj.bmt.1702129 Publication Date: 2002-09-04T15:38:33Z
ABSTRACT
Late onset haemorrhagic cystitis (HC) occurs in 20-30% of allogeneic bone marrow transplant patients. Human polyomavirus BK (BKV) (or less frequently adenovirus) may be involved in the pathogenesis of viral HC and can represent a serious post-transplant complication. Diagnosis and treatment of viral HC can be difficult and has an uncertain outcome. We report the efficacy of sequential vidarabine in the treatment of a patient with severe BKV-associated HC, despite the delay in implementing therapy. Bone Marrow Transplantation (2000) 25, 319-320.
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