Sequential vidarabine infusion in the treatment of polyoma virus-associated acute haemorrhagic cystitis late after allogeneic bone marrow transplantation

• DOI: 10.1038/sj.bmt.1702129
• Publication Date: 2002-09-04T15:38:33Z
• Authors: N Vianelli; M Renga; A Azzi; R De Santis; G Bandini; P Tosi; S Tura
• Keywords: Diarrhea; Male; Polyomavirus Infections; Time Factors; virus; trapianti; Hemorrhage; Antibiotic Prophylaxis; Middle Aged; 3. Good health; Tumor Virus Infections; 03 medical and health sciences; Fatal Outcome; 0302 clinical medicine; Leukemia, Myeloid; Acute Disease; Cystitis; Humans; Transplantation, Homologous; Polyomavirus; Vidarabine; Bone Marrow Transplantation; Hematuria

Late onset haemorrhagic cystitis (HC) occurs in 20-30% of allogeneic bone marrow transplant patients. Human polyomavirus BK (BKV) (or less frequently adenovirus) may be involved in the pathogenesis of viral HC and can represent a serious post-transplant complication. Diagnosis and treatment of viral HC can be difficult and has an uncertain outcome. We report the efficacy of sequential vidarabine in the treatment of a patient with severe BKV-associated HC, despite the delay in implementing therapy. Bone Marrow Transplantation (2000) 25, 319-320.