The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study

Aged, 80 and over Male 0301 basic medicine 2. Zero hunger Aging 0303 health sciences Spectrophotometry, Atomic Osteocalcin Nutritional Status Enzyme-Linked Immunosorbent Assay Middle Aged Alkaline Phosphatase Nutrition Surveys Diet Records Europe 03 medical and health sciences Humans Osteoporosis Female Prospective Studies Amino Acids Biomarkers Chromatography, High Pressure Liquid Aged
DOI: 10.1038/sj.ejcn.1602303 Publication Date: 2005-10-28T11:27:01Z
ABSTRACT
To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects.Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study.Centres in France, Italy and Northern Ireland.A total of 387 healthy adults, aged 55-87 y.Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC.Zinc intake was negatively correlated with urinary Pyr and Dpyr (r = -0.298 and -0.304, respectively; P < 0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r = -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r = -0.090; P < 0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (beta = -0.124; P = 0.011).There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
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