The Role of TSLP in IL-13-Induced Atopic March

• DOI: 10.1038/srep00023
• Publication Date: 2011-07-15T11:39:07Z
• Authors: Zhou Zhu; Min-Hee Oh; Jinho Yu; Yong Jun Liu; Tao Zheng
• Keywords: Thymic stromal lymphopoietin; Interleukin 13; Allergic Inflammation

Although atopic dermatitis (AD) is the initial step of "atopic march", a progression from AD to asthma, underlying mechanism remains unknown. Selective expression IL-13 in skin mice caused an phenotype resembling human AD, and disorder was associated with enhanced production thymic stromal lymphopoietin (TSLP) systemic Th2 immunity. Here we show that transgenic had significantly lung inflammation, mucus hypersecretion, airway hyperresponsiveness (AHR) when sensitized challenged by allergen. In addition, level TSLP higher acute than chronic AD. Furthermore, elimination signaling diminished allergic asthma responses, immune cell cytokines (IL-4, IL-13), serum IgE. These studies indicate induces march via dependent mechanism.