Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium

• DOI: 10.1038/srep00472
• Publication Date: 2012-06-26T12:57:24Z
• Authors: Norman Nausch; Claire D. Bourke; Laura J. Appleby; Nadine Rujeni; Olivier Lantz; François Trottein; Nicholas Midzi; Takafira Mduluza; Francisca Mutapi
• Keywords: Memory T cell

Characterisation of protective helminth acquired immunity in humans or experimental models has focused on effector responses with little work conducted memory responses. Here we show for the first time, that human infection is associated altered proportions CD4+ T cells, an alteration T(H)1 The reduced cell are a significantly lower ratio schistosome-specific IgE/IgG4 (marker resistance to infection/re-infection) uninfected older people. Helminth does not affect CD8+ pool. Furthermore, time decline following curative anti-helminthic treatment despite increased replication. Reduced accumulation cells schistosome-infected people implications development natural vaccine induced as well unrelated pathogens.