Automated and fast building of three-dimensional RNA structures

• DOI: 10.1038/srep00734
• Publication Date: 2012-10-15T10:12:17Z
• Authors: Yunjie Zhao; Yangyu Huang; Zhou Gong; Yanjie Wang; Jianfen Man; Yi Xiao
• Keywords: Automation; 0303 health sciences; 03 medical and health sciences; RNA, Untranslated; Base Sequence; Nucleic Acid Conformation; Article; Algorithms

Building tertiary structures of non-coding RNA is required to understand their functions and design new molecules. Current algorithms of RNA tertiary structure prediction give satisfactory accuracy only for small size and simple topology and many of them need manual manipulation. Here, we present an automated and fast program, 3dRNA, for RNA tertiary structure prediction with reasonable accuracy for RNAs of larger size and complex topology.