Obesity-induced endoplasmic reticulum stress causes chronic inflammation in adipose tissue

• DOI: 10.1038/srep00799
• Publication Date: 2012-11-12T09:15:05Z
• Authors: Noritaka Kawasaki; Rie Asada; Atsushi Saito; Soshi Kanemoto; Kazunori Imaizumi
• Keywords: Adipose tissue macrophages; Homeostasis

Adipose tissue plays a central role in maintaining metabolic homeostasis under normal conditions. Metabolic diseases such as obesity and type 2 diabetes are often accompanied by chronic inflammation adipose dysfunction. In this study, we observed that endoplasmic reticulum (ER) stress the inflammatory response occurred of mice fed high-fat diet for period 16 weeks. After weeks feeding, ER markers increased tissue. We found is induced free fatty acid (FFA)-mediated reactive oxygen species (ROS) generation up-regulated gene expression cytokines 3T3-L1 adipocytes. Oral administration to obese chemical chaperons, which alleviate stress, improved tissue, followed suppression body weight insulin signaling. These results indicate important pathophysiological roles obesity-induced