A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components

• DOI: 10.1038/srep01491
• Publication Date: 2013-03-20T10:05:23Z
• Authors: Eusebio Chiefari; Sinan Tanyolaç; Stefania Iiritano; Angela Sciacqua; Carmelo Capula; Biagio Arcidiacono; Aurora Nocera; Katiuscia Possidente; Francesco Baudi; Valeria Ventura; Giuseppe Brunetti; Francesco S. Brun...; Raffaella Vero; Raffaele Maio; Manfredi Greco; Maria Pavia; Ugur Hodoglugil; Vincent Durlach; Clive R. Pullinger; Ira D. Goldfine; Francesco Perticone; Daniela Foti; Antonio Brunetti
• Keywords: Male; Metabolic Syndrome; 0303 health sciences; Turkey; Middle Aged; Polymorphism, Single Nucleotide; Article; 3. Good health; metabolic syndrome; HMGA1; type 2 diabetes type 2;; 03 medical and health sciences; Italy; Risk Factors; Case-Control Studies; Humans; Female; Genetic Predisposition to Disease; HMGA1a Protein; polymorphism of HMGA1; metabolic syndrome;; Insulin Resistance; Genetic Association Studies; Demography

The metabolic syndrome (MetS) is a common disorder, where systemic insulin-resistance associated with increased risk for type 2 diabetes (T2D) and cardiovascular disease. Identifying genetic traits influencing progression of MetS important. We others previously reported functional HMGA1 gene variant, rs146052672, predisposing to T2D. Here we investigated the association rs146052672 variant related components. In case-control study from Italy Turkey, was seen among carriers variant. larger Italian cohort, this positively correlated BMI, hyperglycemia insulin-resistance, negatively serum HDL-cholesterol. Association between occurred independently T2D, indicating that defects play pathogenetic role in other insulin-resistance-related conditions. Overall, our results indicate represents an early predictive marker MetS, as well tool therapy.