No association between Epstein-Barr Virus and Mouse Mammary Tumor Virus with Breast Cancer in Mexican Women

• DOI: 10.1038/srep02970
• Publication Date: 2013-10-17T09:08:57Z
• Authors: Abigail Morales-S...; Tzindilú Molina-M...; Juan L. E. Martín...; Paulina Hernández...; Alejandra Mantilla; Yelda A. Leal; Javier Torres; Ezequiel M. Fuent...
• Keywords: Etiology; Tumor Virus

Breast cancer is the most frequent malignancy affecting women worldwide. It has been suggested that infection by Epstein Barr Virus (EBV), Mouse Mammary Tumor or a similar virus, MMTV-like virus (MMTV-LV), play role in etiology of disease. However, studies looking at presence these viruses breast have produced conflicting results and this possible association remains controversial. Here, we used polymerase chain reaction assay to screen specific sequences EBV MMTV-LV 86 tumor 65 adjacent tissues from Mexican with cancer. Neither samples nor tissue were positive for either first round PCR only 4 more sensitive nested PCR. Considering study's statistical power, do not support involvement