Metabolic and protein interaction sub-networks controlling the proliferation rate of cancer cells and their impact on patient survival

• DOI: 10.1038/srep03041
• Publication Date: 2013-10-24T09:09:01Z
• Authors: Amir Feizi; Sergio Bordel
• Keywords: Cancer cell lines

Cancer cells can have a broad scope of proliferation rates. Here we aim to identify the molecular mechanisms that allow some cancer cell lines grow up 4 times faster than other lines. The correlation gene expression profiles with growth rate in 60 different has been analyzed using several genome-scale biological networks and new algorithms. New possible regulatory feedback loops suggested known roles cycle related transcription factors confirmed. Over 100 growth-correlated metabolic sub-networks identified, suggesting key role simultaneous lipid synthesis degradation energy supply growth. Many involved line appeared also correlate negatively survival expectancy colon patients.